Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (alphav beta3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegârd, D. (1998) J. Cell Biol. 141, 839-847). The primary structure of bovine osteoadherin has now been determined by nucleo …

2017-02-28 · Osteoadherin (OSAD) is a bone proteoglycan containing keratan sulfate that belongs to the small leucine-rich proteoglycan (SLRP) family. Osteoadherin promotes Integrin αvβ3-mediated cell binding. The central region of Osteoadherin consists of eleven B-type, leucine-rich repeats ranging in length from 20 to 30 residues.

AU - Ramstad, VE. AU - Franzén, Ahnders. AU - Heinegård, Dick. AU - Wendel, M. AU - Reinholt, FP. N1 - The information about affiliations in this record was updated in December 2015. 1999-12-30 · Osteoadherin is a cell binding keratan sulfate proteoglycan which was recently isolated from mineralized bovine bone and subsequently cloned and sequenced. For studies of osteoadherin expression in rat tissues we isolated and sequenced a 1.3-kbp partial cDNA covering most of the coding region using a rat calvaria cDNA library. Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (αvβ3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegård, D. (1998) J. Cell Biol.

Osteoadherin

Osteoadherin, fibromodulin, and chondroadherin, which bind C1q and activate complement, were found to cause significantly higher C9 deposition in C4BP-depleted serum compared with Igs, indicating that the level of complement activation initiated by SLRPs is regulated by simultaneous binding to C4BP. Osteoadherin/OSAD/OMD Polyclonal antibody specifically detects Osteoadherin/OSAD/OMD in Human, Mouse, Rat, Porcine, Bovine, Canine, Equine, Guinea Pig, Rabbit, Zebrafish samples. It … 2012-02-15 Osteoadherin (B-10) is a mouse monoclonal antibody raised against amino acids 221-380 mapping within an internal region of Osteoadherin of human origin. PRODUCT Each vial contains 200 µg IgG 1 kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin. Osteoadherin (B-10) is available conjugated to agarose (sc-271102 AC), 2003-12-12 Sommarin Y, Wendel M, Shen Z, Hellman U, Heinegard D (1998) Osteoadherin, a cell-binding keratan sulfate proteoglycan in bone, belongs to the family of leucine-rich repeat proteins of the extracellular matrix.

Osteoadherin antibody; Osteoadherin proteoglycan antibody; Osteomodulin antibody; SLRR2C antibody. Jan 1, 2019 Osteoadherin (also termed osteomodulin) is encoded by the Omd gene and is a keratan sulfate proteoglycan of the class II subfamily of SLRPs. Mar 30, 2020 localization indicating that this reactivity was due to another KS-proteoglycan, possibly osteoadherin.

May 4, 1998 A small cell-binding proteoglycan for which we propose the name osteoadherin was extracted from bovine bone with guanidine

Gunhild Anker Stordalen, född Melhus den 15 januari 1979 i Haugesund, är en norsk läkare, filantrop och miljöaktivist.Hon är engagerad i frågor rörande klimatförändringar, kvinnohälsa och djurskydd och ordförande i Stordalen Foundation Human Osteoadherin/Osteomodulin ELISA Kit from Invitrogen (96 Tests). Quantitate human OMD in supernatant, serum and plasma. Sensitivity: 1.4 ng/mL OMD (Osteomodulin) is a Protein Coding gene. Diseases associated with OMD include Bladder Carcinoma In Situ and Anthracosilicosis .

NP_005005.1 osteomodulin 229 OMD_HUMAN Osteomodulin precursor ( Osteoadherin) (OSAD) (Keratan sulfate. Q99983 proteoglycan osteomodulin) ( KSPG

Osteoadherin is highly expressed in mineralized tissues, including bone and dentin; however, it's precise roles remain unknown. The present study determined the Omd expression levels and investigated the effects of over‑ and under‑expression of osteoadherin in osteoblastic cells. Osteoadherin, fibromodulin, and chondroadherin, which bind C1q and activate complement, were found to cause significantly higher C9 deposition in C4BP-depleted serum compared with Igs, indicating that the level of complement activation initiated by SLRPs is regulated by simultaneous binding to C4BP.

Quantitate human OMD in supernatant, serum and plasma. Sensitivity: 1.4 ng/mL OMD (Osteomodulin) is a Protein Coding gene. Diseases associated with OMD include Bladder Carcinoma In Situ and Anthracosilicosis . Among its related pathways are Diseases of glycosylation and HIV Life Cycle . An important paralog of this gene is KERA. T1 - Ultrastructural distribution of osteoadherin in rat bone shows a pattern similar to that of bone sialoprotein.
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Osteoadherin promotes Integrin αvβ3-mediated cell binding. The central region of Osteoadherin consists of eleven B-type, leucine-rich repeats ranging in length from 20 to 30 residues. Osteoadherin (OSAD), a keratan sulphate PG is a member of the small leucine-rich (SLRP) family of PGs and unlike other SLRPs, OSAD expression is restricted to mineralized tissues. It is proposed to have a high affinity for hydroxyapatite and has been shown to be expressed by mature osteoblasts but its exact role remains to be elucidated.

It promotes integrin (αvβ3)-mediated cell binding (Wendel, M., Sommarin, Y., … Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucine-rich proteoglycans (SLRP). LRR motifs consist of approximately 20‑30 amino acids (aa) with conserved leucine spacing, folded into a structure with one beta -sheet and one alpha -helix (1, 2). OMD (Osteomodulin) is a Protein Coding gene.
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A: Chelating agents such as EDTA, Heparin and Citrate can bind metal ions from the functional domain of Osteoadherin causing degradation of its protein structure. Osteoadherin may be denatured as a result and may compromise the assay's measurements.

Osteoadherin (B-10) is available conjugated to agarose (sc-271102 AC), 2003-12-12 Sommarin Y, Wendel M, Shen Z, Hellman U, Heinegard D (1998) Osteoadherin, a cell-binding keratan sulfate proteoglycan in bone, belongs to the family of leucine-rich repeat proteins of the extracellular matrix. J Biol Chem 273:16723–16729 PubMed CrossRef Google Scholar Transforming growth factor beta 1 (TGF g 1) is generally considered to be a potent inducer of dentin formation. In order to further assess this role, we studied the influence of this factor in human dental pulp cells on the expression of osteoadherin (OSAD), a newly described proteoglycan found in bone and dentin and suspected to play a role in mineralization events. Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucinerich proteoglycans (SLRP). LRR motifs consist of approximately 2030 amino acids (aa) with conserved leucine spacing, folded into a structure with one βsheet and one Osteoadherin (osteomodulin) is a 49,116-Da protein containing 11 leucine-rich repeats (LRRs), 3-4 tyrosine sulfate residues at the N-terminus, and six potential glycosylation sites for N-linked KS For osteoadherin (also called osteomodulin), a cluster of sulfotyrosines is found in the N-terminal region, while two adjacent sulfotyrosine residues are present in the C-terminal region. Likewise, for the remaining class II and III SLRPs, sulfotyrosines have been predicted in the N-terminal regions.